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Laboratory of chromatographic techniques
Two laboratories for chromatographic techniques, both at analytical and preparative level. IUCT has also capabilities for metal analysis through atomic absorption and stability test according to ICH regulations.
Equipments: HPLC-MS, GC-FID, GC-MS, direct induction MS, HeadSpace for GC, HPLC-UV (allowing high pressure gradients), HPLC-Diode Array (with automatic injection and quaternary pump), Atomic absorption (flame+ hydrides), Atomic absorption (graphite chamber) and ICH compliance climatic chambers
High Throughput Analysis Laboratory
The HTA system integrates HPLC, MS3 , UV-DAD and 400 MHz NMR techniques by means of robotization. This system is the first one ever installed in Spain and it has been designed and created optimizing the interphases between the traditional analytical and characterization systems, in order to achieve a quick analysis and characterization of chemical collections. HTA system provides rapid and high efficient information on the structure and purity of compounds collections.
Laboratory of chemical synthesis
Multifunctional area equipped with automatic reactors to carry out the optimization of chemical processes, high pressure reactors, equipment and instruments for parallel synthesis, parallel evaporation and purification, among others.
The versatility of these areas allows the development of multiple R&D projects focused on drug discovery (traditional combinatorial chemistry, medicinal chemistry, design and preparation of chemical libraries), drug development (Galenic development and preformulation) and green chemistry (development and optimization of ecoefficient synthetic routes, formulation design for biodegradable chemical product, development of new solvent with a low toxicological profile).
Pharmaceutical Pilot Plant
The pilot plant for manufacturing of pharmaceutical products consists on a restricted area with rooms class ISO7 and rooms class ISO8 according to the regulations of ISO 14644-1:1999. The pilot plant complies with current safety and quality requirements in accordance with GMP guidelines which allow the preparation of solid, semisolid and liquid non-sterile pharmaceutical forms. This area also includes a class ISO5 room to carry out the weighting of materials. The pilot plant includes a “V” homogenizer, Sieve, Kneader, Drying Oven, Compressing machine, coating pump, blister conditioning line Alu-Alu and PVC-Alu, 20L and 60L reactors and equipment and instruments for the physical and chemical control on finished product.
Microbiology and biotechnology laboratories
Two laboratories provided with specific equipment for microbiological operations in a non contaminating environment and with adequate environmental and asepsis conditions.
Equipment: Autoclaves, Laminar Flow Cabins, Incubators, Fluorescent Microscopy, Fermentation Test Unit, Revco Freezer, Colonies Counter, Shaker, Thermostated Bath, filtration Ramps, Stomacher, among others.
Scientific and Technical Library
This space is reserved for the consultation and research of bibliographical documentation prior to the development of an R&D Project. The documentation available covers the pharmaceutical chemistry, biology, safety and engineering areas.
The library includes high impact journals in organic chemistry, medicinal chemistry, analytical chemistry, pharmaceutical technology, biotechnology and microbiology, among other.
Featured equipment
NMR
High level 400 MHz NMR with high Speedy flow probe. H-NMR, C-NMR, 2D NMRHPLC - MS3
Liquid Chromatography system with DAD and MS3 detectors connected in line. Injection system thermostatized for vials and microttitler plates.
HIGH TROUGHPUT ANALYSIS (HTA)
It allows the complete characterization of chemical libraries through the spectroscopic data NMR, MS3, UV and purity data through HPLC.
GAS CHROMATOGRAPHY–MASS SPECTROMETRY GC-MS
Gas chromatography coupled with mass spectrometric detector. This system allows also the direct introduction of the sample.GC-FID
Several gas chromatography Systems with FID detector and automatic injection, also allowing HeadSpace system for the analysis of volatiles compounds.HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
HPLC equipment with multiple pumping, automatic sample introduction, thermostated column and DAD detection.ATOMIC ABSORPTION-GRAPHITE OVEN
Determination of metals by means of atomic absorbtion wich incorporates Autosample to allow the process to be monitored.ATOMIC/EMISSION ABSORPTION-FAME-HYDRIDE GENERATION
Equipment for flame atomic absorption/emission with lamps to determine metals by emission, by absorption and by hydride generation in any matrixFTIR
Infrared spectrophotometer using Fourier transformer (FT) in the infrared medium (MIR)UV-DAD
Diode Array Ultraviolet Spectophotometer Continuous determinations through flow cellsREACTOR LAB-MAX
Automated LABMAX reactor for the optimisation of Kilolab scale chemical processes. This equipment is able to control and monitories the reaction parameters.
PRESSURE REACTOR
Equipment for carrying out reactions at high presurre (up to 10 bares and 150ºC)ROBOT COLECTOR ARM
Robotic system for the preparation, dissolution and recollection of samples with the main function of the introduction samples in the NMR equipment of the HTA system. Also used as a robotic support in parallel synthesis for the preparation samples.ORBITAL AGITATION SYSTEM
Semiautomatic orbital agitation system of solid estate reactions (Advanced Chemistry, SPOS) and in Solutions for combinational chemistry reactions or multiple parallel síntesis. It is prepared to carry out 18 simultaneous reactions at the same conditions of agitation and temperature.RADLEY’S CARROUSEL SYSTEM
Versatile equipment used in Medicinal Chemisrty and Chemicals development of processes for the optimisation of the reaction conditions with capacity for 12 simultaneous reactions and with temperature control at high and low temperature, inert temperature, among other properties. This system allows both solid and liquid state reactions.BIOTAGE PARALLEL PURIFICATION SYSTEM
Flash chromatography parallel system which has the possibility of working with 8-12 samples simultaneous.EVAPORATOR-GENOVAC
Equipment used in the massive preparation of the synthesis as it permits the simultaneous evaporation of a multitude of fractions with different configurations. It covers a wide range of solvents including HPLC fractions and DMF.CLIMATIC CHAMBERS
Climatic chambers for stability test studies in accordance with ICH guidelines, calibrated for different temperatura and humidity conditions.DISSOLUTION TEST
Equipment used for the determination of time course of active principle dissolution under pre-established pH and temperature conditionsAUTOMATIC TRITRATOR
Versatile equipment for automatic tritations through different electrodes to carry out potenciometric studies, chloride determination and simple watercontent (Karl Fischer)