SYNTHESIS

Medicinal chemistry

• Design and synthesis of new chemical entities (Hit-finding)
• Design and synthesis to obtain libraries by parallel synthesis
• Hit to lead and lead optimization
• Optimization of synthetic routes and scale up

Custom Synthesis

• Synthesis of building blocks and non commercial scaffolds
• Synthesis of patterns and impurities
• Synthesis of reference compounds and metabolites

New Synthetic Routes

• Set up of new synthetic routes
• Design of new synthetic routes that are not published or patented
• Experimental design and optimization of chemical synthesis: yields, selectivity, crystallization and impurities.
• Minimization of synthesis steps and isolations
• Design and synthesis of new compounds
• Generation reduction of toxic and dangerous by-products
• Processes without salt generation
• Processes without solvents
• Development of processes with minimum solvent consumption
• Optimization of the synthesis methodology in both solid and liquid phase
• Safer reactive compounds

Optimization of chemical processes

• Optimization of processes using LABMAX (kilolab) automatic reactor
• Cost reduction by redesigning of synthetic processes
• Substitution of dangerous reactive compounds
• Development of validation processes and scale up

Revaluation of industry’s by-products

• Use of by-products as raw material for new processes
• New applications for industrial by-products

Structural Elucidation Studies

• Structural elucidation studies 

Chemical biotransformation

• Chemical synthesis using microorganisms
• Fermentation processes
• Biotechnological processes for chemical products of large tonnage (biopolymers, solvents, bio monomers) and fine chemistry
• Obtention of novelty enzymes as industrial biocatalysts for fine chemistry and large productions
• Development of minimal and artificial microorganisms: synthetic biology

Alternative Solvents

• Solvent substitution
• Development of new solvents with low toxicological profile for industrial use
• Synthesis of active principals with safe solvents
• New uses for alternative solvents