InKemia IUCT group works with companies under contract by helping them develop their projects, either focusing in obtaining products that are commercially attractive, solving production problems or developing new processes.

The collaboration modalities go from specific projects developed in a limited period of time to signing a contract that allows collaboration in different projects for a long period of time, 1 or 2 years, allowing more flexibility to introduce new ideas as they appear. Theses modalities are based in the application of working groups in full time equivalent that allow us to adjust to each project’s individual needs. All the intellectual property rights or technical knowledge derived from the project belong to the client from the moment the contract is signed.

Another option to consider is the execution of projects in collaboration mode. In this option there are two possibilities: the first one consists in looking for financing by requesting it from programs that aid R+D, the second one consists in the client and InKemia IUCT group sharing the risk that executing the projects represents. In this last option, in case of success, both parts share the profit and the intellectual property must be negotiated as part of the deal.

InKemia IUCT Group can also licence part of its patented technology. The commercial terms in this option are subject to studying each case.

InKemia IUCT Group is always open to different possibilities and proposals form the companies. Two of our most important values are flexibility and the capacity to adapt ourselves to our client’s needs.

InKemia IUCT group has the following capacities in the Chemicals synthesis sector:

Instrumental Techniques

• LABMAX (kilolab) automatic reactor
  
  • Reactor with computerized control of the reaction variables: temperature of the reaction, temperature of the jacket, agitation speed, flow of the reactive addition, pH control, control probes, distillation control.
  • Reactor from 1-3 L, also pressure reaction up to 1 litre.

• Gas Chromatography- Flame Ionization Detector (GC-FID)
• Gas Chromatography Mass Spectrometry (GC-MS)
• Gas Chromatography, Head Space
• HPLC-UV
• HPLC, Mass Spectrometry (MS)
• Flame Atomic absorption spectroscopy
• Graphite furnace atomic absorption spectrometry
• FT-IR
• molecular absorption spectroscopy, UV-Visible
• NMR (400 MHz)

InKemia IUCT Group offers services of isolation, identification and characterization of the following products, among others:

• Impurities of pharmaceutical products
• Natural products
• Fractions of natural products extracts
• Additives

The main areas of development in industrial biotechnology of InKemia IUCT group are:

• New microorganism prospects and enzymes derived from extreme environments
• Obtention of novelty enzymes as industrial biocatalysts to be used in the fine chemistry sector or related.
• Purified expression of proteins
• Design and optimization of biocatalysts
• Design of biocatalyst processes
• Scale-up studies for biotechnological processes

Techniques of specialization:

• Cloning of host cells both prokaryotic and eukaryotic
• Cloning of vectors
• Constitutive and inductive expression of proteins in prokaryotes and yeasts
• Primer design
• Set-up of biotransformation reactions mediated by microorganisms or purified fractions of microorganisms.
• Biosynthesis of APIs both antiviral and anti-cancer
• Biosynthesis of monomers and vitamin K3
• Purification of products and metabolites
• Identification of Products and metabolites
• Creation of fusion proteins
• Quantitative and qualitative determination of DNA, RNA and proteins
• Ames Test

InKemia IUCT group counts with authorized facilities by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) (Spanish Agency for medicinal drugs and Sanitary Products) to produce pharmaceutical products. The manufacturing and quality control practices performed at InKemia IUCT group are according to GMP guidelines.

We have the following accreditations: 

• ISO 9001:2008 certification for the design, research and development of new products, control systems and training for the pharmaceutical, alimentary, chemical and related sectors (Nº SGI 3201316). Certification by Lloyd’s Register
• Authorization by the AEMPS to manufacture and perform quality control in medicinal drugs for human consumption since 2004 (Nº 4155-E)
• Authorization by the AEMPS to manufacture and perform quality control in veterinary medicinal drug since 2012 (Nº 4155-E)
• Authorization by the AEMPS to manufacture and perform quality control in medicinal under research since 2012-(Nº 4155-E)

The activities that we can develop are:

Manufacturing Facilities

The manufacturing facilities at InKemia IUCT group include ISO7 and ISO8 rooms for the production of solid, semisolid and non sterile liquid pharmaceutical products. The equipment in these facilities includes “V” mixer, rotating compressor, fine coating machine, blister machine, drying ovens, liquid and semisolid reactor, and laminar flow cabin.

Quality control laboratory

Instrumental analysis techniques:
FT-IR, UV-diode array, UV-VIS, polarimeter, HPLC-MS3, GC-FID, GC-MS, MS, HPLC-UV, HPLC-diode array, atomic absorption (flame+hydride and graphite furnace)

Other equipment and techniques:
Solution test, digesters, drying ovens, moulding, automatic titration, viscometer, hardness testers, disintegration tests, friability tester, microscopes, laminar flow cabins, incubators, filtering systems.

Chemical synthesis laboratory

The equipment includes, among others, solid-phase parallel synthesizer, liquid-phase parallel synthesizer (carrousel system), parallel synthesizer (IR incubator), Lab-Max reactor, flash parallel purification system, centrifugal evaporator, HPLC-MS-NMR (400 MHz). 

Biotechnological synthesis laboratory

The equipment includes, among others, thermal cycler, agarose gel electrophoresis equipment, polyacrylamide gel electrophoresis equipment, laminar flow cabin, bioreactor, incubator.

InKemia IUCT group counts with authoruized facilities by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) Sanitarios (Spanish Agency for medicinal drugs and Sanitary Products)   to perform control of cosmetic products. The quality control practices performed at InKemia IUCT group are according to GMP guidelines.

We have the following accreditations:

• ISO 9001:2008 certification by Lloyd’s Register for the design, research and development of new products, control systems and training for the pharmaceutical, alimentary, chemical and related sectors (Nº SGI 3201316).
• Authorization by the AEMPS to perform quality control in cosmetic products since 2007 (Nº 4155-E).

 The activities that we can develop are:

Desenvolupament galènic

Manufacturing

• Support in Studies for process validation

Quality control

• Physicochemical and microbiological control of cosmetic products
• Start-up and development of methods for analysis
• Validation of physicochemical and microbiological analysis methods
• Analytical support in validation of processes and cleanliness

Stability studies under ICH conditions

• Product storage according to ICH regulations
• Product testing
• Development of study protocol
• Drafting of study report

Consultancy

• Support in applications that require commercial authorization
• Recommendation for GMP establishment
• Recommendation for GLP establishment

Synthesis of APIs

• Chemical and biochemical development and scale up for APIs synthesis
• Validation and scale up studies
• Synthesis optimization
• APIs characterization
• Isolation, characterization and synthesis of impurities and degradation products

Facilities

• Manufacturing pilot plant (GMP)
• Laboratories for physicochemical quality control
• Laboratories for microbiological quality control
• Laboratories for the chemical development and biochemical synthesis of APIs

Manufacturing Facilities

The manufacturing facilities at InKemia IUCT group include ISO7 and ISO8 rooms for the production of solid, semisolid and non sterile liquid pharmaceutical products. The equipment in these facilities includes “V” mixer, rotating compressor, fine coating machine, blister machine, drying ovens, liquid and semisolid reactor, and laminar flow cabin.

Quality control laboratory

Instrumental análisis techniques:
FT-IR, UV-diode array, UV-VIS, polarimeter, HPLC-MS3, GC-FID, GC-MS, MS, HPLC-UV, HPLC-diode array, atomic absorption (flame+hydride and graphite furnace)

Other equipment and techniques:
Solution test, digesters, drying ovens, moulding, automatic titration, viscometer, hardness testers, disintegration tests, friability tester, microscopes, laminar flow cabins, incubators, filtering systems.

Chemical synthesis laboratory

The equipment includes, among others, solid-phase parallel synthesizer, liquid-phase parallel synthesizer (carrousel system), parallel synthesizer (IR incubator), Lab-Max reactor, flash parallel purification system, centrifugal evaporator, HPLC-MS-NMR (400 MHz).

Biotechnological synthesis laboratory

The equipment includes, among others, thermal cycler, agarose gel electrophoresis equipment, polyacrylamide gel electrophoresis equipment, laminar flow cabin, bioreactor, incubator.

InKemia IUCT group also counts with ISO 9001:2008 certification by Lloyd’s Register for the design, research and development of new products, control systems and training for the pharmaceutical, chemical, alimentary and related sectors (Nº SGI 3201316).

Analytical Techniques

• Gas Chromatography- Flame Ionization Detector (GC-FID)
• Gas Chromatography Mass Spectrometry (GC-MS)
• Gas Chromatography, Head Space
• HPLC-UV
• HPLC, Mass Spectrometry (MS)
• Flame Atomic absorption spectroscopy
• Graphite furnace atomic absorption spectrometry
• FT-IR 
• Molecular absorption spectroscopy, UV-Visible
• NMR (400 MHz)Cromatografía de gases, espectrometría de masas(GC-MS)

InKemia IUCT group has been authorized by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) (Spanish Agency for medicinal drugs and Sanitary Products) to perform quality control of cosmetic products (Nº 4155-E).

InKemia IUCT group also counts with ISO 9001:2008 certification by Lloyd’s Register for the design, research and development of new products, control systems and training for the pharmaceutical, chemical, alimentary and related sectors (Nº SGI 3201316).

Analytical Techniques

• Gas Chromatography- Flame Ionization Detector (GC-FID)
• Gas Chromatography Mass Spectrometry (GC-MS)
• Gas Chromatography, Head Space
• HPLC-UV
• HPLC, Mass Spectrometry (MS)
• Flame Atomic absorption spectroscopy
• Graphite furnace atomic absorption spectrometry
• FT-IR
• Molecular absorption spectroscopy, UV-Visible
• NMR (400 MHz)