Licensing Out

Licensing Out is the Department of IUCT in charge of negotiating the license of products & technologies obtained as a result of its research activity.

From the projects that are carried out in InKemia IUCT group we obtain new products, processes and technologies that become part of the group’s pipeline and can be patented, used as know-how or become part of a new technological platform. All these new technologies could later become part of the industry through a technological transfer process or a license.

InKemia IUCT has found a wide variety of exopolysaccharides (EPS), products with a high potential as active ingredients in several fields like human and veterinary drugs, cosmetics, and functional foods among others. We have about 100 different compounds up to date, the majority of them ready to be tested. Through different co-development agreements InKemia IUCT has started several research lines to study the use of our EPS in Alzheimer’s disease and cosmetic applications and we will start new researches soon to increase the use of the EPS.

We have a variable number of compounds already synthetized for their use in the research of new drugs

To get more information about these EPS click here.

InKemia’s IUCT group knowledge division now reaches the number of 62 patents granted.

These granted patents are of international nature and reach over 20 different countries, some of these patents have long term potential and can be exploited until the year 2030.

It is important to note that a great number of these patents are currently under revision and their gradual approval is expected over the next few months. Both the patents in process and the granted ones can be concentrated into 25 groups that are multiplied as they are presented throughout different countries, therefore all the patents could result in over 150 patents by the end of the process.

The 62 granted patents are grouped into three important areas of development

Drug Discovery-Biomedicine
Industrial biotechnology and Biofuels
Green Chemistry and “Green products”

Libraries of small molecules with potential for anti-inflammatory activity “N-(1-Fenil-2-oxo-3-piperidil) sulfonamides for the identification of biological and pharmaceutical activity”

Patent Num.	Country of granting	Granting year	Expiration year
1	USA	2013	2030

Libraries of small molecules with potential for anti-inflammatory activity “N-Fenil-1-sulfonil-2-pirrolidinacarboxamidas for the identification of biological and pharmaceutical activity”

Patent Num.	Country of granting	Granting year	Expiration year
2	USA	2013	2030

New biocatalysts for the obtention of pharmaceutical active principles anticarcinogenic and antivirus “Thermostable biocatalyst combination for nucleoside synthesis”

Patent Num.	Country of granting	Granting year	Expiration year
3	USA	2013	2030

New second generation biofuel. “Obtention of fatty acid esters from glycerol formal and used as biofuel”

Patent Num.	Country of granting	Granting year	Expiration year
4	USA	2012	2027
5-31	European patent (all 27 countries)	2011	2027
32	Australia	2011	2027
33	Hong Kong	2011	2027
34	Japan	2013	2027
35	Mexico	2011	2027
36	Malaysia	2011	2027
37	New Zealand	2011	2027
38	Canada	2013	2027
39	Vietnam	2013	2027
40	South Korea	2013	2027

Synthesis of pharmaceutical intermediaries by means of green chemistry. “Procedure of Friedel-Crafts reaction in ionic liquids”

Patent Num.	Country of granting	Granting year	Expiration year
62	USA	2009	2025

Biosynthesis of K3 vitamin. “Microbiological procedure for the preparation of menadione”

Patent Num.	Country of granting	Granting year	Expiration year
41	Spain	2010	2024
42	Germany	2010	2024

New green solvents for degreasing metals. “Compositions for degreasing hard surfaces”

Patent num.	Country of granting	Granting year	Expiration year
43	Germany	2011	2028
44	Spain	2011	2028
45	France	2011	2028
46	UK	2011	2028
47	Ireland	2011	2028
48	Italy	2011	2028
49	Holland	2011	2028
50	Poland	2011	2028
51	Switzerland	2011	2028

Synthesis of pharmaceutical active principles by means of green chemistry. “Process for the preparation of LOPERAMIDE”

Patent num.	Country of granting	Granting year	Expiration year
52	Germany	2012	2027
53	Spain	2012	2027
54	Italy	2012	2027
55	UK	2012	2027
56	Switzerland	2012	2027

Synthesis of pharmaceutical active principles by means of green chemistry. “Process for the preparation of the PIMOZIDE”

Patent num.	Country of granting	Granting year	Expiration year
57	Germany	2013	2027
58	Spain	2013	2027
59	Italy	2013	2027
60	UK	2013	2027
61	Switzerland	2013	2027

Countries

- Inkemia Brasil

- Inkemia Colombia

LABORATORY

Two laboratories for chromatographic techniques, both at analytical and preparative level. IUCT has also capabilities for metal analysis through atomic absorption and stability test according to ICH regulations.

Equipments: HPLC-MS, GC-FID, GC-MS, direct induction MS, HeadSpace for GC, HPLC-UV (allowing high pressure gradients), HPLC-Diode Array (with automatic injection and quaternary pump), Atomic absorption (flame+ hydrides), Atomic absorption (graphite chamber) and ICH compliance climatic chambers

The HTA system integrates HPLC, MS3 , UV-DAD and 400 MHz NMR techniques by means of robotization. This system is the first one ever installed in Spain and it has been designed and created optimizing the interphases between the traditional analytical and characterization systems, in order to achieve a quick analysis and characterization of chemical collections. HTA system provides rapid and high efficient information on the structure and purity of compounds collections.

Multifunctional area equipped with automatic reactors to carry out the optimization of chemical processes, high pressure reactors, equipment and instruments for parallel synthesis, parallel evaporation and purification, among others.

The versatility of these areas allows the development of multiple R&D projects focused on drug discovery (traditional combinatorial chemistry, medicinal chemistry, design and preparation of chemical libraries), drug development (Galenic development and preformulation) and green chemistry (development and optimization of ecoefficient synthetic routes, formulation design for biodegradable chemical product, development of new solvent with a low toxicological profile).

The pilot plant for manufacturing of pharmaceutical products consists on a restricted area with rooms class ISO7 and rooms class ISO8 according to the regulations of ISO 14644-1:1999. The pilot plant complies with current safety and quality requirements in accordance with GMP guidelines which allow the preparation of solid, semisolid and liquid non-sterile pharmaceutical forms. This area also includes a class ISO5 room to carry out the weighting of materials. The pilot plant includes a “V” homogenizer, Sieve, Kneader, Drying Oven, Compressing machine, coating pump, blister conditioning line Alu-Alu and PVC-Alu, 20L and 60L reactors and equipment and instruments for the physical and chemical control on finished product.

Two laboratories provided with specific equipment for microbiological operations in a non contaminating environment and with adequate environmental and asepsis conditions.

Equipment: Autoclaves, Laminar Flow Cabins, Incubators, Fluorescent Microscopy, Fermentation Test Unit, Revco Freezer, Colonies Counter, Shaker, Thermostated Bath, filtration Ramps, Stomacher, among others.

This space is reserved for the consultation and research of bibliographical documentation prior to the development of an R&D Project. The documentation available covers the pharmaceutical chemistry, biology, safety and engineering areas.

The library includes high impact journals in organic chemistry, medicinal chemistry, analytical chemistry, pharmaceutical technology, biotechnology and microbiology, among other.

High level 400 MHz NMR with high Speedy flow probe. H-NMR, C-NMR, 2D NMR

Liquid Chromatography system with DAD and MS3 detectors connected in line. Injection system thermostatized for vials and microttitler plates.

It allows the complete characterization of chemical libraries through the spectroscopic data NMR, MS3, UV and purity data through HPLC.

Gas chromatography coupled with mass spectrometric detector. This system allows also the direct introduction of the sample.

Several gas chromatography Systems with FID detector and automatic injection, also allowing HeadSpace system for the analysis of volatiles compounds.

HPLC equipment with multiple pumping, automatic sample introduction, thermostated column and DAD detection.

Determination of metals by means of atomic absorbtion wich incorporates Autosample to allow the process to be monitored.

Equipment for flame atomic absorption/emission with lamps to determine metals by emission, by absorption and by hydride generation in any matrix

Infrared spectrophotometer using Fourier transformer (FT) in the infrared medium (MIR)

Diode Array Ultraviolet Spectophotometer Continuous determinations through flow cells

Automated LABMAX reactor for the optimisation of Kilolab scale chemical processes. This equipment is able to control and monitories the reaction parameters.

Equipment for carrying out reactions at high presurre (up to 10 bares and 150ºC)

Robotic system for the preparation, dissolution and recollection of samples with the main function of the introduction samples in the NMR equipment of the HTA system. Also used as a robotic support in parallel synthesis for the preparation samples.

Semiautomatic orbital agitation system of solid estate reactions (Advanced Chemistry, SPOS) and in Solutions for combinational chemistry reactions or multiple parallel síntesis. It is prepared to carry out 18 simultaneous reactions at the same conditions of agitation and temperature.

Versatile equipment used in Medicinal Chemisrty and Chemicals development of processes for the optimisation of the reaction conditions with capacity for 12 simultaneous reactions and with temperature control at high and low temperature, inert temperature, among other properties. This system allows both solid and liquid state reactions.

Flash chromatography parallel system which has the possibility of working with 8-12 samples simultaneous.

Equipment used in the massive preparation of the synthesis as it permits the simultaneous evaporation of a multitude of fractions with different configurations. It covers a wide range of solvents including HPLC fractions and DMF.

Climatic chambers for stability test studies in accordance with ICH guidelines, calibrated for different temperatura and humidity conditions.

Equipment used for the determination of time course of active principle dissolution under pre-established pH and temperature conditions

Versatile equipment for automatic tritations through different electrodes to carry out potenciometric studies, chloride determination and simple watercontent (Karl Fischer)

Stainless steel pump with air treatment filter EU3 and EU7. This equipment is also provided with a dosage dispenser with a Watson Marlow peristaltic pump and a software controlled system.
Equipped with 10 stations and 8 mm biconvex burin punch, able to reach maximum speed of 30 rpm.
With a useful capacity of 50L, this reactor is provided with an ancora central agitation, Turrax homogeniser agitation and doublé wall for temperatura control.

Automatic machine for shaping blisters in PVC or in aluminum with a máximum size of 250x160mm
Use for a perfect homogenization of the solid products, this equipment has a capacity of 5L.
La Planta Piloto dispone de dos estufas de secado com uma capacidad de 108 Litros cada uma y com um rango de temperaturas desde temperatura ambiente hasta 220ºC.
Com um caudal de 1.475 m3/hora, 0,40 m/s de velocidad de aire y filtros HEPA/ULPA H14 99,999%, esta cabina de seguridad biológica cuenta com dos ventiladores de alta eficácia, uno de impulsión y outro de extracción.

EQUIPMENT

LABORATORIO 37, fotos octubre 2005

DSCF0798 DE MARZO 08, mirar de borrar TECKNOKROMA

LABORATORIO 68, fotos octubre 2005

SALA PILOTO 23, fotos octubre 2005

Two laboratories provided with specific equipment for microbiological operations in a non contaminating environment and with adequate environmental and asepsis conditions.

LABORATORIO 98 fotos octubre 2005 / DSCF0672 fotos marzo 2008

The library includes high impact journals in organic chemistry, medicinal chemistry, analytical chemistry, pharmaceutical technology, biotechnology and microbiology, among other.

LABORATORIO 31 / 32 fotos octubre 2005